| abstract |
The present invention provides, among other things, convergent processes for the preparation of eptifibatide that involves the coupling of an fragment 2-6 eptifibatide to an activated cysteinamide residue in order to form an fragment 2-7 eptifibatide, annexing a mercaptopropionic acid residue. to the 2-7 eptifibatic fragment through disulfide bond formation, coupling the peptide intramolecularly and removing the protective group, to form the eptifibatic. The invention also provides products produced by the processes described, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatico and novel compounds that are structurally similar to eptifibatide. |