| abstract |
The present invention describes substituted 4-alkyl- and 4-alkanoyl-piperidine derivatives having neuroquinine antagonist activity, in particular, NK1 antagonist activity and NK1 / NK3 combined antagonist activity; with compositions comprising said derivatives and with their use as a medicament, especially for the treatment or prophylaxis of schizophrenia; the vomit; anxiety and depression; irritable bowel syndrome (IBS), circadian rhythm disturbances; preeclamsia; nociception; pain, in particular, visceral and neuropathic pain; pancreatitis; neurogenic inflammation; asthma; chronic obstructive pulmonary disease (COPD), and urination disorders, such as urinary incontinence; The compounds according to the invention can be represented by the general Formula (I): (see formula (I)) and also comprise their pharmaceutically acceptable base or acid addition salts; its stereochemically isomeric forms; its N-oxide form; and its prodrugs, wherein all substituents are defined in accordance with claim 1. |