| abstract |
A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind to this epitope fall within the scope of the invention and may be murine, chimeric or humanized antibodies, immunoconjugates of the antibodies or their antigen binding fragments. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammals. |