| abstract |
In accordance with the present invention, tetracyclic carboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use have been provided; In one aspect of the invention, these useful compounds are provided in the inhibition of VEGF production, in the inhibition of angiogenesis, and / or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration; In another aspect of the invention, methods are provided for inhibition of VEGF production, inhibition of angiogenesis, and / or treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention. |