| abstract |
The present invention is related to novel compounds derived from aryl piperidine or piperazine substituted with certain 5-membered heterocycles that have an inhibitory activity of apoB / MTP secretion and a concomitant anti-lipidemic activity; furthermore, the invention relates to methods for the preparation of such compounds, pharmaceutical compositions that include said compounds, as well as the use of said compounds as medicaments for the treatment of hyperlipidemia, obesity and type II diabetes (formula (I)) ; (See formula (I)) The invention also relates to methods for preparing such compounds, to pharmaceutical compositions comprising said compounds as well as to the use of said compounds as a medicament for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. |