| abstract |
A composition for the topical application of botulinum toxin (including derivatives of botulinum toxin) comprises a botulinum toxin and a vehicle comprising a polymeric structure comprising a long chain polypeptide or a non-peptidyl polymer having adhered "efficiency" groups. "or positively charged branching groups. The present invention also relates to methods for reducing muscle paralysis and other conditions that can be treated with butolin toxins, particularly, subcutaneous paralysis and more particularly, facial or muscular paralysis by topically applying an effective amount of toxin from botulinum and vehicle, together, to the skin or epithelium of the subject. Equipment for administration is also described. |