| abstract |
The present invention relates to novel oxazolidinone derivatives, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have excellent efficiency in their solubility against water. In addition, derivatives of the present invention can exert potent antibacterial activity against various pathogens of humans and animals, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such as Bacteroides and Clostridia, and acid resistant microorganisms such as Mycobacterium tuberculosis and Mycobacterium avium. Accordingly, compositions comprising oxazolidinone are used in an antibiotic. |