| abstract |
The present invention relates to diagnostic imaging agents. Image-forming agents comprise a synthetic caspase-3 inhibitor labeled with an image-forming portion suitable for the formation of diagnostic images, in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising image forming agents, with equipment for the preparation of radiopharmaceuticals. Caspase-3 inhibitor chelator conjugates are also described, which are suitable for the preparation of imaging agents comprising a radioactive or paramagnetic metal ion. The imaging agents are useful for the formation of diagnostic images and / or verification of in vivo therapy of various disease states in which caspase-3 is involved. |