| abstract |
The invention relates to a group of hydronopol derivatives which are agonists on human ORL1 (nociceptin) receptors; The invention relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these novel hydronopol derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in the which ORL1 receptors participate; The invention relates to compounds of the general formula (1) (see formula I) wherein the symbols have the meanings provided in the description. |