| abstract |
The present invention is directed to substituted derivatives of N-heterocycles of the formula (I) (see formula (I)), compositions containing these derivatives, and their use in the manufacture of a medicament for the prevention and treatment of conditions improved by monoamine reabsorption including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, urinary and tension urinary incontinence, fibromyalgia, pain, diabetic neuropathy and combinations thereof where: A is phenyl, naphthyl, thiophenyl, pyridinyl, furanyl, benzofuranyl, isobenzofuranyl, xanthenyl, pyrrolyl, indolizinyl, isoindolyl, indolyl, or benzothiophenyl, where 1 to 3 at A carbon atoms are optionally replaced with a nitrogen atom; U is N or O; W is H or OR8; the other substituents are defined in the claims. |