http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-PA06002559-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c834eb81d6424e6d4f4cefe9cd06e34d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-61 |
| filingDate | 2004-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_298eea94b0828a642a58acaac988324a |
| publicationDate | 2006-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-PA06002559-A |
| titleOfInvention | SELECTION SYSTEM CONTAINING SELECTION MARKER WITHOUT ANTIBIOTIC RESISTANCE. |
| abstract | The present invention relates to a system of free selection of antibiotic resistance genes, which is based on the use of an araD gene as a selection marker carried on a vector which is inserted into a bacterial strain deficient in the gene. araD. The araD gene of E. coli encodes L-ribulose-5-phosphate-4-epimerase. It also refers to a method for selecting cells transformed with a plasmid, which contains the araD gene. The selection marker without antibiotics makes the system suitable for developing therapeutic products. The araD gene is not essential for host growth but its manipulation affects growth under certain selective conditions. The suppression of the araD gene leads to the accumulation of a substance that is toxic to the host but not to humans. The araD gene is relatively small and therefore a small plasmid can be constructed, which requires less energy for replication and leads to increased growth rate and yield. |
| priorityDate | 2003-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 368.