| abstract |
The invention relates to a group of 1H-imidazole derivatives that are modulators of cannabinoid receptors, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazole derivatives, to methods for the preparation of these intermediates. , to pharmaceutical compositions containing one or more of these 1H-imidazole derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of neurological psychiatric disorders in which cannabinoid receptors are involved; the compounds have the general formula (I) (see general formula (I)), wherein R, R1-R4 and X have the meanings given in the specification. |