| abstract |
Pharmaceutically acceptable compounds and salts of the formula are described (see formula (A)) that are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia, the compounds of the invention include inhibitors of the tyrosine phosphatase protein, in particular tyrosine phosphatase-1B protein (PTP-1B), which are useful in the treatment of diabetes and other PTP-mediated diseases, such as cancer, neurodegenerative diseases and the like. Pharmaceutical compositions comprising compounds of the invention and methods of treating the above-mentioned conditions using such compounds are also described. |