| abstract |
(See Formula I) Pharmaceutically acceptable compounds and salts of formula (I) are described that are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance or hyperglycemia. Compounds of the invention include inhibitors of tyrosine phosphatase proteins, in particular tyrosine phosphatase 1B (PTP-1B) proteins that are useful in the treatment of diabetes and other diseases mediated by PTP, such as cancer, diseases neurodegeneratives and the like. Pharmaceutical compositions comprising the compounds of the invention and methods of treating the aforementioned conditions using such compounds are also described. |