| abstract |
The present invention relates to a pyrimidine derivative of formula (I): (see formula (I)) and its salts, which are useful as an active ingredient in pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 antagonist activity (chemoattractant receptor coupled to protein G, which is expressed in Th2 cells) and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases such as asthma, allergic rhinitis, atopic dermatitis and allergic conjunctivitis; diseases related to eosinophils such as Churg-Strauss syndrome and sinusitis; Basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in humans and other mammals, and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflamed bowel disease, ulcerative colitis, Crohn's disease, TPOC (chronic obstructive pulmonary disorder) and arthritis. |