| abstract |
This invention relates to substituted pyrimidinone and pyrimidinothione derivatives that bind with high affinity to CRF1 receptors, including CRF1 receptors in humans, this invention also relates to methods for using the compounds of the invention in the treatment of a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders and depression and stress-related disorders. |