abstract |
A compound of formula (I) (see formula (I)) or a pharmaceutically acceptable derivative thereof, in which U represents - (CH2) d (O) 2-, -CO-, or -CH (C1- alkyl) 6) -; W represents -O-, -S (O) a-, or -N (R1) -; R1 represents H, C1-6 alkyl, (CH2) bCOR2, CO (CH2) bNR2R3, SO2R2, (CH2) cOR2, (CH2) cNR2R3, or (CH2) bhet1; het1 represents a saturated or unsaturated heterocycle of 3 to 8 atoms containing one or more heteroatoms selected from O, N, or S, optionally substituted with C1-6 alkyl; X and Y independently represent H, C1-6 alkyl, halogen, OH, CF3, OCF3, OR4; Z represents - (- CH2) f (O) g-, -CO- or -CH (C1-6 alkyl) -; Ring A represents 4-7 members, saturated and containing N, optionally substituted with OH, and in which optionally at least one N of the ring is substituted with O; Ring B represents phenyl or a 4-7 membered heterocycle, unsaturated and containing N, optionally substituted with OH, halogen, CN, CONH2; CF3, OCF3, and in which optionally at least one N of the ring is substituted with O; R2 and R3 independently represent H, C1-6 alkyl, [optionally substituted with OH, halogen, N (C1-6 alkyl) 2, or C1-6 oxy alkyl], C1-6oxy alkyl, N (alkyl C1-6) 2, or [C3-8 cycloalkyl]; or R2 and R3, together with the nitrogen atom to which they are attached independently represent a heterocycle of 3 to 8 atoms, optionally substituted with C1-6 alkyl; R4 represents linear or branched C1-6 alkyl; a and c independently represent 0, 1 or 2; b, e and g independently represent 0 or 1; d and f independently represent 1 or 2; which are useful in the treatment of dysmenorrhea. |