http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-PA05008411-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_257e52a8fcb6658dc74983b64fd511b7 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
filingDate | 2004-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72dc649bd0797343f2beb3984064e4be |
publicationDate | 2005-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | MX-PA05008411-A |
titleOfInvention | PROCEDURE FOR THE PREPARATION OF A CIANOISOBENZOFURAN. |
abstract | A process for the preparation of citalopran and the pharmaceutically acceptable salts thereof is described, by reacting 5-cyanophthalide with a 4-fluorophenylmagnesium halide, reducing 3-hydroxymethyl-4 (4-fluorobenzoyl) benzonitrile with a ketone reducing agent. To alcohols, send 3-hydroxymethyl-4 - [(4-fluorophenyl) hydroxymethyl) benzonitrile obtained in this way to a cyclization reaction to provide 1- (4-fluorophenyl) -1,3-dihydro-5-isobenzofurannocarbonitrile without 1 , 1-bis (4-fluorophenyl) -1,3-dihydro-5-isobenzofurancarbonitrile and treat 1,1-bis (4-fluorophenyl) -1,3-dihydro-5-isobenzofurannocarbonitrile with a 3- (dimethylamino) halide ) propyl in the presence of a base. |
priorityDate | 2003-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.