| abstract |
The present invention relates to solid oral dosage forms. The solid dosage forms are sugar free, and comprise a pharmaceutical agent and a suitable pharmaceutically acceptable excipient. Preferably, the solid dosage forms of the present invention are bioequivalent to a sugar-containing dosage form. Preferably, bioequivalence is obtained by incorporating an ionizing agent, more preferably in the form of a buffer system, in solid dosage forms, in an amount sufficient to maintain a portion of the pharmaceutical agent in the ionized state, after dissolution of Said composition in saliva. |