| abstract |
The present invention provides compounds of formula (I): (see formula (I)), prodrugs thereof and pharmaceutically acceptable salts of the compounds and prodrugs, wherein R ', R' ', R' '' and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof in the treatment of diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis and tissue ischemia. |