| abstract |
Derivatives of (1H-benzoimidazol-2-yl) - (piperazinyl) -methanone of formula (I) and related compounds are described as histamine H4 receptor antagonists for the treatment of inflammatory and allergic disorders, wherein B and B1 are C , or even one of B and B1 can be N; Y is O, S or NR2, where R2 is H or C1-4 alkyl; Z is O or S; R8 is H and R9 is (II), where R10 is H or C1-4 alkyl, or R5 and R9 are taken together with their union N to form (III); n is 1 or 2; m is 1 or 2; n + m is 2 or 3; the other substituents are as defined in claim 1. (See Formula). |