| abstract |
The present invention provides a pharmaceutical dosage form comprising a filler material sealed in a gelatin capsule; The filler material comprises (a) a selective COX-2 selective water-soluble inhibitor drug and (b) a primary or secondary amine compound in an amount sufficient to inhibit the cross-linking of the gelatin in said gelatin capsule after storage of the pharmaceutical form in a closed container maintained at 40 degree C and relative humidity of 75% for a period of 6 months. |