| abstract |
Derivatives of azulene represented by the following formula (1) (See Formula) and salts thereof are useful as inhibitors of co-transporter of Na + -glucose in, for example, remedies for diabetes, etc., in particular, diabetes independent of insulin (type 2 diabetes), insulin dependent diabetes (type 1 diabetes), etc., and remedies for various diabetes-related diseases such as insulin-resistant disease and obesity. These compounds are characterized in that a tile ring is attached, either directly or by means of an optionally halogenated lower alkylene, to a benzene ring and the benzene ring is directly attached to a sugar residue. |