| abstract |
The present invention relates to acylamino substituted heteroaromatic compounds of the formula (1), (See Formula) in which, R1, R1, R3, R3 and R3, and X have the meanings indicated in the claims . The compounds of the formula (I) are active, valuable pharmaceutical compounds, useful in the treatment of different disease states that include cardiovascular disorders, such as atherosclerosis, thrombosis, coronary arteriopathies, hypertension and heart failure. These effect the upregulation of the expression of the endothelial enzyme nitric oxide (NO) synthase, and can be used in states where the increase in the expression of the enzyme, or the increase in the concentration of NO, or normalization is desired. of a decreased concentration of NO. The invention also relates to the processes for the preparation of the compounds of the formula (I), their use, in particular, as active ingredients in pharmaceuticals, and the pharmaceutical preparations containing them. |