| abstract |
Compounds are provided that are useful as antidiabetic agents having structure (1), wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH2) X where x is 1 to 5, or A is (CH2) X1 where x1 is 1 to 5 with an alkenyl bond or an alkynyl bond included anywhere in the chain, or A is - (CH2) X2 -o- (CH2) X3- where x2 is O at 5 and x3 is O at 5, with the proviso that at least one of x2 and x3 is different from O; B is a bond or is (CH2) 4 where X4 is 1 to 5; X is CH or N; X2 is C, N, 0 or 5; X3 is C, N, O or S; X4 is C, N, O or 5; X5 is C, N, 0 or 5; X6 is C, N, 0 or 5; with the proviso that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C, and specifically excluding structure (II) where: X2 = N, X3 C, X4 O or S, Z O or a link; R1 is H or alkyl; is H, alkyl, R2 is H, alkyl, alkoxy, halogen, amino or cyano or substituted amino; R2a, R2b and R2c may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, amino or substituted cyano; R3 and Y are as defined herein, such compounds are useful in the treatment of diabetes and obesity. |