| abstract |
This invention relates to monospecific, monovalent and multivalent antibodies, and multivalent, multispecific antibodies. One modality of these antibodies has one or more identical binding sites, where each binding site binds with a target antigen or with an epitope in a target antigen. Another modality of these antibodies has two or more binding sites, where these binding sites have affinity for different epitopes in a target antigen or different target antigens; or have an affinity for a white antigen and a hapten. The present invention also relates to recombinant vectors, useful for the expression of these functional antibodies in a host. More specifically, the present invention relates to the antibody designated PAM4, associated with tumor. The invention further relates to humanized and human PAM4 antibodies, and to the use of such antibodies in diagnosis and therapy. . |