| abstract |
Non-peptide GnRH regulators capable of inhibiting the effect of gonadotropin-releasing hormone are described; such compounds and their pharmaceutically acceptable salts, prodrugs and metabolites are suitable for treating reproductive disorders in mammals and steroid hormone dependent tumors, as well as for regulating fertility, when the suppression of gonadotropin release is indicated; Methods for synthesizing the compounds and intermediates useful for their preparation are also described. |