| abstract |
The invention provides compounds of formula (I) :( see formula I) in which: A and B represent the groups - (CH2) m- and (CH2) n-, respectively; R1 represents hydrogen or C1-6 alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxy-C1-6 alkyl, trifluoromethyl, trifluoromethoxy, C1-6 alkyl, C1-6 alkoxy, fluoroalkoxy C1-6, -SO2-C1-6 alkyl, -SO- alkyl C1-6, -S-C1-6 alkyl, -CO2-C1-6 alkyl, CO2NR5R6, SO2NR5R6, - (CH2) pNR5R6, - (CO2) pNR5R6, an optionally substituted aryl ring, an optionally substituted heteroaryl ring or an optionally substituted heterocyclyl ring, R3 represents an optionally substituted aryl ring or an optionally substituted heteroaryl ring, R4 represents hydrogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, trifluoromethyl, trifluoromethoxy, halogen, -OSO2CF3, - (CH2 ) p- C3-6 cycloalkyl, - (CH2) qO-C3-6 alkyl, or - (CH2) pO-C3-6 cycloalkyl, R5 and R6 each independently represent hydrogen, C1-6 alkyl, or. Together with the nitrogen atom or others to which they are attached, they form an azacycloalkyl ring or an oxo substituted azacycloalkyl ring; Z represents - (CH2) rX- in which the group (CH2) r- is linked to R3, or -X (CH2) r- where X is linked to R3 and where any of the -CH2 groups can optionally be substituted with one or more C1-6 alkyl groups; X represents oxygen, NR7 or -CH2-, in which the group -CH2- can be optionally substituted with one or more C1-6 alkyl groups, R7 represents halogen or C1-6 alkyl; m and n independently represent an integer selected between 1 and 2; p independently represents an integer selected from 0, 1 2 and 3; q independently represents an integer selected from 1, 2 and 3; r independently represents an integer selected from 0, 1 and 2; or a pharmaceutically acceptable salt or solvate thereof; The compounds are useful and therapy, in particular as antipsychotic agents. |