| abstract |
Recombinant chimeric protein composed of a 60 amino acid fragment from the N-terminal region of human interleukin 2 (IL-2) fused to the N-terminal region of the extracellular region of the receptor alpha chain for IFN gamma (IFN and); this protein in vitro has growth stimulating activity of T cells, inhibits growth stimulating activity of IL-2 in T cells, inhibits the induction of HLA-DR by IFN and inhibits the antiproliferative activity of IFN and; This invention can be applied in the medical field for the treatment of various pathologies such as autoimmune diseases, transplant rejection, chronic inflammations, sepsis, ischemia and reperfusion syndrome and atherosclerosis. |