| abstract |
The present invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient in pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonists and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence by impulse, superactive bladder, chronic pain, neuropathic pain , postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischemia, neurodegeneration, stroke, incontinence, inflammatory disorders such as asthma and COPD. |