http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-PA04010308-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2003-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8755e8a192925c639b88d2cb4f1d4cd9 |
| publicationDate | 2005-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-PA04010308-A |
| titleOfInvention | ANTIGONISTS OF THE TRICICLIC THROMBINE RECEIVER. |
| abstract | The heterocyclic substituted tricyclics of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: the dotted line represents an optional single bond; (a) represents an optional double bond; n is 0-2; Q is cycloalkyl, optionally substituted by R13 and R14; each R13 is independently selected from H, (C1-C6) alkyl, (C3-C8) cycloalkyl, - (CH2) n6NHC (O) OR16b, - (CH2) n6NHC (O) R16b, - (CH2) n6NHC ( O) NR4R5, - (CH2) n6NHSO2R16, - (CH2) n6NHSO2NR4R5, and - (CH2) n6C (O) NR28R29 where n6 is 0-4, haloalkyl and halogen; Each R14 is independently selected from H, (C1-C6) alkyl, -OH, (C1-C6) alkoxy, R27-aryl-C1-C6 alkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, (C1-) alkyl C6), cycloalkyl (C3-C8), - (CH2) n6NHC (O) OR16b, - (CH2) n6NHC (O) R16b, - (CH2) n6NHC (O) NR4R5, - (CH2) n6NHSO2R16, - (CH2) n6NHSO2NR4R5, and - (CH2) n6C (O) NR28R29; wherein n6 is 0-4, halogen and haloalkyl; R13 and R14 together form a scyclic or heteroespirocyclic ring of 3-6 atoms; wherein at least one of R13 or R14 is selected from the group consisting of (C1-C6) alkyl, cycloalkyl (C3-C8), - (CH2) n6NHC (O) OR16b, - (CH2) n6NHC (O) R16b , - (CH2) n6NHC (O) NR4R5, - (CH2) n6NHSO2R16, - (CH2) n6NHSO2NR4R5, - (CH2) n6C (O) NR28R29 where n6 is 0-4; Het is an optionally substituted mono or bicyclic heteroaryl group; and B is an optionally substituted bond, alkylene or alkynylene or alkynylene; wherein the rest of the substituents are as defined in the specification, as described, as well as pharmaceutical compositions containing them and a method for the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythma, heart failure and cancer by administering said compounds; Combination therapy with other cardiovascular agents is also claimed. |
| priorityDate | 2002-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 224.