| abstract |
The invention relates to new imitations of acyl coenzyme-A, compositions comprising ketone compounds, and methods useful for the treatment and prevention of circulatory conditions, dyslipidemias and glucose metabolism conditions, which comprises administering a composition comprising a ketone compound. Imitations of acyl coenzyme-A, the compositions and methods of the invention are also useful for the treatment and prevention of Alzheimer's disease, Syndrome X, conditions related to the peroxisome proliferator activated receptor, septicemia , thrombotic conditions, obesity, pancreatitis, hypertension, kidney disease, cancer, inflammation, bacterial infection and impotence. In certain embodiments, imitations of acyl coenzyme-A, the compositions and methods of the invention are useful in combination therapy with other therapeutic agents, such as hypocholesterolemic and hypoglycemic agents. |