abstract |
A modified polysaccharide, in particular a modified polysaccharide from serogroup A of Neisseria meningitidis, which retains immunogenicity, but has improved stability. Typically, the modified polysaccharide is prepared by reacting a capsular polysaccharide, or an oligosaccharide fragment thereof, with a bifunctional reagent such as CDI, followed by reaction with an amino compound, such as dimethylamine. Modified polysaccharide-protein conjugates and vaccines prepared from these conjugates are also described. |