| abstract |
The present invention relates to novel pyrazolo [1,5-a] pyridine derivatives of the general formula I which bind with high affinity to CRF1 receptors, including human CRF receptors. This invention also relates to methods of using the compounds of the invention to treat a disease or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS diseases or disorders, particularly anxiety and depression diseases. and diseases related to stress. |