http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-PA04008409-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f213d0e99b22bbbe3bb14718e4986b85 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M15-08 |
| filingDate | 2004-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d53d8f15b33a17828941aec05f7ba1ea |
| publicationDate | 2005-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-PA04008409-A |
| titleOfInvention | A PHARMACEUTICAL FORMULATION IN ADEQUATE AEROSOL FOR ORAL OR NASAL INHALATION CONTAINING GLUCOCORTICOIDS IN A STABLE SOLUTION TO STORAGE; A METHOD FOR STABILIZING FORMULATIONS AND USE OF A STABILIZING AGENT. |
| abstract | Aerosol formulations containing glucocorticoids in solution stabilized by the addition of water or a mixture of water and citric acid are described, without corrosion of the packaging elements after subjecting them to storage conditions. The formulations comprise: between 0.05 and 1.0% by weight of a glucocorticoid having a ketone group on carbon 20 and an OH on carbons 17 and / or 21, as active substance; -between 0.10 and 3% by weight of a stabilizing agent selected from water, or a mixture of water and organic acid selected from citric acid and tartaric acid. -a cosolvent in efficient quantity to solubilize the active substance; - optionally a surfactant and .propellant in sufficient quantity to reach 100% by weight in the final solution. Glucocorticoids with a keto group in carbon 20 and an OH in carbons 17 and / or 21, with a variety of substituents, which have proven to be highly susceptible to chemical degradation when formulated as aerosol products in solution, have several well-known therapeutic uses, especially those related to their anti-inflammatory activity. These glucocorticoids, and their pharmaceutical formulations are useful in the treatment of various diseases that include bronchial disorders and inflammatory processes. Preferably the glucocorticoid is selected from Triamcinolone Acetonide, Budesonide, Dexamethasone and Betamethasone 17-Valerate. Method for stabilizing pharmaceutical formulations for aerosols glucocorticoids in solution susceptible to oxidative degradation. Use of a stabilizing agent selected from water or a mixture of water and an organic acid selected from citric acid and tartaric acid. |
| priorityDate | 2003-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.