| abstract |
The present invention relates to pharmaceutical compositions and methods for the transmucosal delivery of proton pump inhibitors; in one embodiment, the pharmaceutical composition of the present invention comprises a core containing an antacid, and an outer layer that adheres to the core; the outer layer contains a therapeutically effective amount of a proton pump inhibitor; in another embodiment, the pharmaceutical composition of the present invention comprises an outer layer including a unidirectional film, and an inner layer containing a therapeutically effective amount of a proton pump inhibitor; in another further embodiment, the pharmaceutical composition of the present invention is a tablet for unidirectional delivery of a proton pump inhibitor through the oral mucosa; in this embodiment, the pharmaceutical composition contains an outer layer containing an impermeable layer to the pharmaceutically acceptable water, and an inner layer containing a therapeutically effective amount of a proton pump inhibitor. |