abstract |
The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein X represents two hydrogen atoms, a sulfur atom, an oxygen atom or a C1-2 alkyl group and an atom of hydrogen; And it represents a union, an ethenylene group, an ethinylene group, an oxygen atom, a sulfur atom, a sulfonyl group, a sulfoxide group, a carbonyl group, an nitrogen atom optionally; or an optionally substituted methylene group; R1 represents an optionally substituted pyrimidine group; R2 may represent a C1-6 alkyl group optionally substituted by an aryloxy or a C6.10 arylamino group, a C3-6 cycloalkyl group, a C1-4 alkylthio group, C1-4 alkoxy group, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a phenylthio group, a benzyl group, a benzene ring, an indan ring, a 5,6,7,8-tetrahydronaphthalene ring, naphthalene ring, a pyridine ring, a ring pyrrole, a thiophene ring, a furan ring or an imidazole ring; R3 and R4 each independently represent a hydrogen atom, a C1-6 alkyl group, a hydroxy group, a C1-4 alkoxy group or a halogen atom; R5 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom. The invention also relates to a medicament comprising said derivative or a salt thereof as an active ingredient that is used for the preventive and / or therapeutic treatment of a neurodegenerative disease caused by the abnormal activity of GSK3? or the GSK3 ?? and cdk5 / p25, such as Aizheimer's disease. |