| abstract |
Isolated human monoclonal antibodies that specifically bind to IL-15 (eg, human IL-15), and compositions and molecules based on related antibodies are disclosed. Human antibodies can be produced in a transfectome or in a non-human transgenic animal, for example, a transgenic mouse, which can produce multiple isotypes of human monoclonal antibodies by V-D-J recombination and isotype switching. Pharmaceutical compositions comprising human antibodies, non-human transgenic animals, and hybridomas that produce human antibodies and therapeutic and diagnostic methods for the use of human antibodies are also disclosed. |