http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-PA03011770-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
| filingDate | 2002-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba43f2a20737b2fac0439a8aea0c64f9 |
| publicationDate | 2004-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-PA03011770-A |
| titleOfInvention | PROCESS FOR THE PREPARATION OF CITALOPRAM RACEMICO AND / OR S- OR R-CITALOPRAM BY SEPARATION OF A MIXTURE OF R- AND S-CITALOPRAM. |
| abstract | The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and / or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-citalopram with more than 50% of one of the enantiomers in a fraction consisting of racemic citalopram and / or a fraction of S-citalopram or R-citalopram, characterized in that i) citalopram is precipitated in a solvent as the free base or as an acid addition salt thereof; ii) the precipitate formed is separated from the mother liquor; iia) if the precipitate is crystalline it is optionally recrystallized one or more times to form racemic citalopram, and then optionally converted into an acid addition salt thereof; iib) if the precipitate is not crystalline, steps i) and ii) are repeated, optionally, until a crystalline precipitate is obtained and the crystalline precipitate is recrystallized one or more times to form racemic citalopram and then optionally converted into a salt of addition of the acid thereof; iii) the mother liquor is optionally subjected to further purification and is isolated S-citalopram or R-citalopram from the mother liquor and optionally converted into an acid addition salt thereof. |
| priorityDate | 2001-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.