| abstract |
A compound represented by Structural Formula (I) has been described: (see formula) Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, -CH2- or -CH2CH2-; W is a substituted or unsubstituted alkylene linker group or a substituted or unsubstituted heteroalkylene linker group two to ten atoms in length, preferably two to seven atoms in length. The Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W. R1 is - (CH2) n-CH (OR2) - (CH2) mE, - (CH) = C (OR2) - (CH2) mE , - (CH2) n-CH (Y) - (CH2) mE or - (CH) = C (Y) - (CH2) mE; where E is COOR3, (C1-C3) alkyl nitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and where sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and C0-C4 arylalkyl ; R2 is -H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, -COR4, -COOR4, -CONR5R6, -C (S) R4, -C (S) OR4 or -C (S) NR5R6. R3 is -H, an aliphatic group, a substituted aliphatic group, a group, aromatic or a substituted aromatic group. And it is -O-, -CH2-, -CH2CH2- or -CH = CH- and is attached to a carbon atom in the Phenyl Ring A which is ortho with respect to R1. R4-R6 are independently -H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2. |