| abstract |
compounds of the general structural formula (I) and the use of the compounds and salts and solvates thereof as therapeutic agents are described. In particular, the invention relates to compounds that are potent and selective inhibitors of the 3Æ, 5Æ-cyclic guanosine phosphodiesterase (cGMP specific PDE), in particular PDE5, and are useful in a variety of therapeutic areas in the which such inhibition is considered beneficial, including the treatment of cardiovascular disorders and erectile dysfunction. |