| abstract |
The present invention provides compounds of the formula I: or a pharmaceutically acceptable derivative thereof, wherein X is oxygen or sulfur; Y is -S-, -O- NR1-; and R2, R3, and R4 are as described in the specification. These compounds are protein kinase inhibitors, in particular mammalian GSK-3 protein kinase inhibitors. The invention also provides pharmaceutical compositions comprising inhibitors of the invention and methods for using those compositions in treatment and prevention of various disorders, such as, for example, diabetes and Alzheimer's disease. |