| abstract |
Topical patch preparations are provided containing a delayed-type hypersensitivity inducer, for example, 1-dichloro-2,4-dinitrobenzene (DNCB), and methods of use thereof; The present topical patch preparations consist of an adhesive gel composition that is present on a support, wherein the adhesive gel composition includes the delayed-type hypersensitivity inducer, a water-soluble, water-soluble polymer gel and a retention agent. Water; During the use of the present topical patch preparations, the topical patch preparations are applied to a skin surface of a subject, and are maintained at the application site for a period sufficient for an effective amount of the hypersensitivity inducer to delayed type is administered to the subject, where this maintenance period does not typically exceed about 60 minutes; The present invention finds use in a variety of applications, where administration of a delayed-type hypersensitivity inducer is desired, and is particularly suitable for use in the treatment of disease conditions associated with HIV, for example, AIDS. |