| abstract |
A triheterocyclic compound of formula (I) is provided: (see formula) wherein each of W, X and Y is carbon or nitrogen; each of U and Z is CR2, NR13, nitrogen, oxygen, sulfur, etc .; ring A is a carbocyclic ring, a heterocyclic ring; R1 is alkyl, alkenyl, alkynyl, NR4R5, OR6, etc .; R3 is a carbocyclic ring, heterocyclic ring; and a pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical substance comprising them as an active ingredient. A compound of formula (I) is useful in order to possess antagonistic activity of corticotropin releasing factor receptor to prevent or treat depression, anxiety, eating disorders, post-traumatic stress disorder, peptic ulcer, bowel syndrome irritable, Alzheimer's disease, drug addiction or alcohol dependence syndrome, etc. |