| abstract |
This invention relates to liposomal formulations of mitoxantrone and methods for its manufacture and use; The compositions of the present invention include liposomal formulations of mitoxantrone in which the liposome contains any of the variety of materials that form neutral or charged liposomes in addition to a compound thought to bind to mitoxantrone, such as cardiolipin; Liposomal compositions can be conveniently used together with secondary therapeutic agents other than mitoxantrone, including antineoplastic, antifungal, antibiotic agents among other active agents; methods are provided in which a therapeutically effective amount of the formulation is administered to a mammal, such as a human being. |