| abstract |
The present invention relates to an adrenergic receptor # 3 agonist of formula I: (see formula) or a pharmaceutical salt thereof, which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is ° useful for the treatment of Type II diabetes and / or obesity. The compound can also be used to reduce triglyceride levels and cholesterol levels and to raise high density lipoprotein levels, or to reduce intestinal motility. In addition, the compound can be used to reduce neurogenic inflammation or as an antidepressant agent. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for reducing triglyceride levels and cholesterol levels and for raising high density lipoprotein levels or for reducing intestinal motility are also described. |