| abstract |
This invention relates to novel cyclic malonamides of the formula (I): their pharmaceutical compositions and their methods of use. These novel compounds inhibit the processing of the amyloid precursor protein and, more specifically, inhibit the production of peptide A (, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological conditions related to the production of (-amiloid such as Alzheimer's disease and Down syndrome. |