| abstract |
The present invention claims and describes a pharmaceutical composition suitable for oral administration, in the form of an emulsion pre-concentrate, comprising: (i) one or more FAINEs that release ON; (ii) one or more surfactants; (iii) optionally an additional semi-solid oil or grease; The composition forms an oil-in-water emulsion in situ with contact with gastrointestinal fluids. The composition may also optionally comprise one or more short chain alcohols. Also within the scope of the invention is a combination with a proton pump inhibitor. The pharmaceutical composition is useful in the treatment of pain and inflammation. Furthermore, within the scope of the invention is a device comprising a pharmaceutical composition according to the invention in a unit dosage form, in combination with a proton pump inhibitor, and the proton pump inhibitor has a coating. enteric. |