abstract |
The present invention provides dihydro-2H-naphthalene-1-ones of the formula and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues in diseases such as cancer, atherosclerosis, restenosis and psonasis. Specifically, the present invention relates to compounds that inhibit the enzyme farnesyl transferase. |