| abstract |
The use of a compound of the formula (I) is described, wherein R 1, R 2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicine, for the treatment or prophylaxis of diseases or conditions in which the inhibition of the activity of the nitric oxide synthase enzyme is beneficial. Certain novel compounds of the formula (Ia) and pharmaceutically acceptable salts, enantiomers and racemates thereof are described; together with the procedures for their preparation, compositions containing them and their use in therapy. The compounds of the formulas (I) and (Ia) are inhibitors of the nitric oxide synthase enzyme and with which they are particularly useful in the treatment or prophylaxis of an inflammatory disease. |